New Polymer Synthetic Strategy
We aim to develop a scalable and concise synthetic strategy to prepare functionalized polyesters from amino acids through controlled living polymerization of O-carboxyanhydrides monomers and other cyclic monomers.
Video protocols for photoredox ring-opening polymerization
References:
Zhong, Y.; Feng, Q.; Wang, X.; Chen, J.; Cai, W.; Tong, R. “Functionalized Polyesters via Stereoselective Electrochemical Ring-Opening Polymerization of O-Carboxyanhydrides”, ACS Macro Letters, 2020, 9, 1114-1118.
Feng, Q.; Yang, L.; Zhong, Y. L.; Guo, D.; Liu, G. L.; Xie, L. H.; Huang, W.; Tong, R. "Stereoselective Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides", Nature Communications, 2018, 9, 1559.
Feng, Q.; Tong, R. "Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides", J. Am. Chem. Soc. 2017, 139, 6177-6182
Wang, R.; Zhang, J.; Yin, Q.; Xu, Y.; Cheng, J.; Tong, R. “Controlled Ring-Opening Polymerization of O-Carboxyanhydrides Using β-Diiminate Zinc Catalyst", Angew. Chem. Int. Ed., 2016, 55, 5452-5456.
Tong, R.; Cheng, J. Macromolecules, 2012, 45, 2225-2232.
Tong, R.; Cheng, J. Chemical Science, 2012, 3, 2234-2239.
Lu, Y.; Yin, L.; Zhang, Y.; Tong, R.; Xu, Y.; Cheng, J. ACS Macro Letters, 2012, 1, 441.
Tong, R.; Cheng, J. Bioconjugate Chemistry, 2010, 21, 111-121
Tong, R.; Cheng, J. J. Am. Chem. Soc., 2009, 131, 4744-4754.
Tong, R.; Cheng, J. Angew. Chem. Int. Ed., 2008, 47, 4830-4834.
Zhong, Y.; Feng, Q.; Wang, X.; Chen, J.; Cai, W.; Tong, R. “Functionalized Polyesters via Stereoselective Electrochemical Ring-Opening Polymerization of O-Carboxyanhydrides”, ACS Macro Letters, 2020, 9, 1114-1118.
Feng, Q.; Yang, L.; Zhong, Y. L.; Guo, D.; Liu, G. L.; Xie, L. H.; Huang, W.; Tong, R. "Stereoselective Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides", Nature Communications, 2018, 9, 1559.
Feng, Q.; Tong, R. "Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides", J. Am. Chem. Soc. 2017, 139, 6177-6182
Wang, R.; Zhang, J.; Yin, Q.; Xu, Y.; Cheng, J.; Tong, R. “Controlled Ring-Opening Polymerization of O-Carboxyanhydrides Using β-Diiminate Zinc Catalyst", Angew. Chem. Int. Ed., 2016, 55, 5452-5456.
Tong, R.; Cheng, J. Macromolecules, 2012, 45, 2225-2232.
Tong, R.; Cheng, J. Chemical Science, 2012, 3, 2234-2239.
Lu, Y.; Yin, L.; Zhang, Y.; Tong, R.; Xu, Y.; Cheng, J. ACS Macro Letters, 2012, 1, 441.
Tong, R.; Cheng, J. Bioconjugate Chemistry, 2010, 21, 111-121
Tong, R.; Cheng, J. J. Am. Chem. Soc., 2009, 131, 4744-4754.
Tong, R.; Cheng, J. Angew. Chem. Int. Ed., 2008, 47, 4830-4834.
Light-triggered Drug Delivery
The ability to trigger drug release from a device (i.e. on-demand drug delivery) can enable control over the exact timing (onset and offset) and magnitude of therapeutic effect, and also provide spatio-temporal control which can enhance the therapeutic index. We aim to develop nanoparticulate triggerable drug delivery systems that respond to external energy sources for drug delivery and tissue penetration. This can be potentially applied in ocular drug delivery and chemotherapy.
References:
Li, L. L.; Tong, R. (co-first author); Chu, H.; Langer, R.; Kohane, D. S. Proceedings of the National Academy of Sciences of the U. S. A. 2014, 111, 17099-17103.
Tong, R.; Chiang, H. H.; Kohane, D. S. Proceedings of the National Academy of Sciences of the U. S. A. 2013, 110, 19048-19053.
Tong, R.; Hemmati, H. D.; Langer, R. S.; Kohane, D. S. J. Am. Chem. Soc., 2012, 134, 8848-8855.
Li, L. L.; Tong, R. (co-first author); Chu, H.; Langer, R.; Kohane, D. S. Proceedings of the National Academy of Sciences of the U. S. A. 2014, 111, 17099-17103.
Tong, R.; Chiang, H. H.; Kohane, D. S. Proceedings of the National Academy of Sciences of the U. S. A. 2013, 110, 19048-19053.
Tong, R.; Hemmati, H. D.; Langer, R. S.; Kohane, D. S. J. Am. Chem. Soc., 2012, 134, 8848-8855.